Liberty BioSecurity Senior Advisory Board Member, ​Dr. Ari Patrinos, is the Director of the Center for Urban Science and Progress, and a professor of biological, chemical and mechanical engineering at NYU. He is considered to be a leading authority on structural biology, genomics, global environmental change, and nuclear medicine. This oral history follows his time as Director of the Office of Biological and Environmental Research in the U.S. Department of Energy (DOE), where he worked on the Human Genome Project and initialed the International Panel on Climate Change and the Global Change Research Program. In this interview Ari discusses how the DOE ended up working with NIH on the Human Genome Project, his research, and his relationships with Francis Collins, Craig Venter and Harold Varmus.